Table 4 Changes of DNAm in the IL1B and IL6 gene after neurosurgery.
| Â | all | Â | Â | Â | POD | Â | Â | Â | non-POD | Â | Â | Â |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|  | N = 37 |  |  |  | N = 10 |  |  |  | N = 27 |  |  |  |
| Â | pre | post | post-pre | paired-t | pre | post | post-pre | paired-t | pre | post | post-pre | paired-t |
cg | mean | mean | diff | p value | mean | mean | diff | p value | mean | mean | diff | p value |
IL1B | ||||||||||||
cg01290568 | 26.4 | 16.1 | −10.3 | *<0.0001 | 26.2 | 12.7 | −13.4 | *<0.0001 | 26.5 | 17.3 | −9.1 | *0.0001 |
cg02596281 | 84.3 | 82.6 | −1.7 | 0.01 | 84.4 | 81.8 | −2.6 | 0.15 | 84.2 | 82.9 | −1.3 | 0.05 |
cg07250315 | 37.7 | 33.2 | −4.5 | *<0.0001 | 39.9 | 33.0 | −6.9 | *0.0004 | 36.9 | 33.3 | −3.6 | 0.004 |
cg07935264 | 9.0 | 6.5 | −2.6 | *0.0001 | 8.8 | 5.5 | −3.2 | 0.02 | 9.2 | 6.8 | −2.4 | 0.002 |
cg10486274 | 93.7 | 93.1 | −0.6 | 0.09 | 93.9 | 93.1 | −0.7 | 0.40 | 93.6 | 93.1 | −0.5 | 0.15 |
cg14117934 | 86.3 | 85.5 | −0.8 | 0.37 | 86.7 | 85.8 | −0.9 | 0.41 | 86.1 | 85.4 | −0.7 | 0.53 |
cg15218327 | 92.1 | 88.6 | −3.5 | *<0.0001 | 92.4 | 89.6 | −2.8 | 0.01 | 92.0 | 88.2 | −3.7 | *<0.0001 |
cg15836722 | 26.3 | 20.1 | −6.2 | *<0.0001 | 27.3 | 17.1 | −10.1 | *0.0001 | 26.0 | 21.2 | −4.7 | 0.003 |
cg18635064 | 94.6 | 94.3 | −0.3 | 0.36 | 93.2 | 92.4 | −0.8 | 0.26 | 95.1 | 95.0 | −0.1 | 0.76 |
cg18773937 | 7.2 | 4.8 | −2.3 | *0.0001 | 6.8 | 4.2 | −2.5 | 0.03 | 7.3 | 5.1 | −2.3 | 0.002 |
cg19890119 | 15.6 | 8.8 | −6.8 | *<0.0001 | 15.9 | 6.7 | −9.2 | *<0.0001 | 15.5 | 9.6 | −5.9 | *0.0004 |
cg20157753 | 5.4 | 4.8 | −0.6 | 0.06 | 5.9 | 4.2 | −1.7 | 0.02 | 5.2 | 5.0 | −0.2 | 0.56 |
cg20983042 | 87.1 | 87.0 | 0.0 | 0.95 | 87.5 | 86.8 | −0.6 | 0.69 | 86.9 | 87.1 | 0.2 | 0.82 |
cg23149881 | 14.8 | 8.4 | −6.3 | *<0.0001 | 14.1 | 6.8 | −7.4 | 0.003 | 15.0 | 9.1 | −6.0 | *0.0001 |
IL6 | ||||||||||||
cg00087425 | 6.4 | 6.6 | 0.2 | 0.62 | 6.3 | 6.2 | −0.1 | 0.84 | 6.5 | 6.8 | 0.3 | 0.54 |
cg00175482 | 89.0 | 86.8 | −2.2 | 0.002 | 88.6 | 85.7 | −2.9 | 0.047 | 89.1 | 87.3 | −1.9 | 0.02 |
cg01770232 | 7.1 | 7.6 | 0.5 | 0.09 | 7.7 | 7.7 | 0.1 | 0.90 | 6.9 | 7.5 | 0.6 | 0.04 |
cg02335517 | 93.4 | 92.7 | −0.7 | 0.02 | 93.3 | 93.0 | −0.3 | 0.42 | 93.4 | 92.5 | −0.9 | 0.03 |
cg03601896 | 3.8 | 3.0 | −0.8 | 0.02 | 4.0 | 2.7 | −1.3 | 0.03 | 3.7 | 3.1 | −0.6 | 0.14 |
cg05265849 | 20.2 | 17.6 | −2.5 | *0.0001 | 21.4 | 16.9 | −4.5 | *0.0005 | 19.7 | 17.9 | −1.8 | 0.02 |
cg07998387 | 69.5 | 70.2 | 0.6 | 0.28 | 69.8 | 68.6 | −1.3 | 0.31 | 69.4 | 70.7 | 1.4 | 0.04 |
cg10140158 | 87.7 | 87.9 | 0.2 | 0.70 | 86.8 | 87.0 | 0.2 | 0.79 | 88.0 | 88.2 | 0.2 | 0.77 |
cg13104385 | 39.9 | 39.1 | −0.8 | 0.15 | 41.1 | 38.4 | −2.6 | 0.02 | 39.5 | 39.4 | −0.1 | 0.84 |
cg15703690 | 9.6 | 5.8 | −3.8 | *<0.0001 | 10.0 | 4.6 | −5.4 | 0.001 | 9.5 | 6.2 | −3.2 | *0.0003 |
cg17067544 | 78.7 | 83.3 | 4.6 | *<0.0001 | 79.3 | 85.0 | 5.7 | 0.01 | 78.5 | 82.7 | 4.2 | *<0.0001 |
cg20509117 | 62.3 | 61.9 | −0.4 | 0.68 | 62.2 | 62.5 | 0.2 | 0.90 | 62.3 | 61.6 | −0.7 | 0.59 |
cg21785978 | 5.4 | 5.1 | −0.3 | 0.44 | 5.2 | 4.4 | −0.8 | 0.27 | 5.5 | 5.3 | −0.1 | 0.78 |
cg23731304 | 37.6 | 34.5 | −3.1 | *0.0002 | 38.7 | 33.5 | −5.2 | 0.005 | 37.2 | 34.9 | −2.3 | 0.01 |
