Table 3 Genetic predicted MetS and its components on the risk of depression in the MR analysis.

From: The association between depression and metabolic syndrome and its components: a bidirectional two-sample Mendelian randomization study

Exposure

Outcome

No.SNP

Methods

OR (95% CI)

p val

Egger_intercept

p-Egger_intercept

MetS

Depression

73

MR Egger

1.022 (0.976–1.071)

0.356

−0.001

0.660

   

IVW (Q = 173.68, p < 0.001)

1.013 (0.989–1.039)

0.296

  
   

Weighted median

1.018 (0.993–1.044)

0.157

  
   

Simple mode

1.018 (0.968–1.070)

0.484

  
   

Weighted mode

1.012 (0.987–1.039)

0.350

  

Waist circumference

Depression

30

MR Egger

0.713 (0.539–0.942)

0.025

0.013

0.004

   

IVW (Q = 68.78, p < 0.001)

1.099 (0.998–1.209)

0.054

  
   

Weighted median

1.040 (0.949–1.139)

0.402

  
   

Simple mode

1.062 (0.929–1.215)

0.383

  
   

Weighted mode

1.041 (0.927-–1.170)

0.502

  

Hypertension

Depression

10

MR Egger

0.868 (0.748–1.007)

0.099

0.009

0.183

   

IVW (Q = 7.02, p = 0.635)

0.966 (0.930–1.003)

0.071

  
   

Weighted median

0.948 (0.900–0.998)

0.043

  
   

Simple mode

0.939 (0.861–1.025)

0.192

  
   

Weighted mode

0.942 (0.873–1.017)

0.162

  

FBG

Depression

118

MR Egger

1.116 (1.034–1.204)

0.006

−0.003

0.006

   

IVW (Q = 243.76, p < 0.001)

1.022 (0.976–1.070)

0.354

  
   

Weighted median

1.052 (1.002–1.106)

0.043

  
   

Simple mode

1.045 (0.962–1.136)

0.300

  
   

Weighted mode

1.061 (1.017–1.107)

0.007

  

Triglycerides

Depression

26

MR Egger

1.031 (0.977–1.087)

0.281

0.000

0.784

   

IVW (Q = 34.41, p = 0.099)

1.036 (0.999–1.075)

0.059

  
   

Weighted median

1.027 (0.985–1.071)

0.205

  
   

Simple mode

1.023 (0.939–1.115)

0.605

  
   

Weighted mode

1.028 (0.993–1.064)

0.129

  

HDL-C

Depression

60

MR Egger

0.994 (0.946–1.045)

0.817

0.001

0.382

   

IVW (Q = 106.44, p < 0.001)

1.011 (0.978–1.045)

0.517

  
   

Weighted median

1.010 (0.975–1.047)

0.581

  
   

Simple mode

1.031 (0.954–1.115)

0.443

  
   

Weighted mode

1.005 (0.972–1.039)

0.778

  
  1. IVW inverse-variance weighted, MetS metabolic syndrome, FBG fasting blood glucose, HDL-C high-density lipoprotein cholesterol.
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