Table 2 Summary of binding constants.

From: Conformational heterogeneity coupled with β-fibril formation of a scaffold protein involved in chronic mental illnesses

 

VHH B5 KD [nM] (n)

NDEL1 KD [µM] (n)

LIS1 KD [nM] (n)

Monomer (M)

46 (1.4)

20 (1.4)

71 (1.2)

Oligomer/Fibril (H)

66 (1.1)

13 (2.1)

31 (2.4)

Oligomer/Fibril (M)

70 (1.1)

14 (2.5)

31 (2.8)

  1. Legend: n – cooperativity index, M – MBP fusion construct, H – His6 fusion construct.
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