Table 1 Associations between PRSs and autism-related phenotypes at GWAS p-value threshold 0.05, adjusted for 10 genetic principal components.

From: Genetic liability to rheumatoid arthritis on autism and autistic traits: polygenic risk score and Mendelian randomization analyses

 

Rheumatoid arthritis PRS for mothers

Rheumatoid arthritis PRS for offspring

Outcome

N

RR (95% CIs)

P

N

RR (95% CIs)

P

Autism cases

7685

0.89 (0.73–1.07)

0.21

7849

1.11 (0.88–1.39)

0.39

SCDC

5071

0.98 (0.90–1.07)

0.95

5450

1.02 (0.94–1.10)

0.67

Coherence

4992

0.95 (0.87–1.03)

0.21

5568

1.01 (0.94–1.09)

0.76

Repetitive behaviour

5249

0.96 (0.86–1.06)

0.40

5557

1.06 (0.97–1.17)

0.21

Sociability

5965

0.96 (0.89–1.03)

0.27

6176

0.99 (0.92–1.06)

0.75

  1. PRSs polygenic risk scores, GWAS genome-wide association study, N sample size in analysis, RR relative risk, (95% CIs) 95% confidence intervals, P p-value, SCDC social communication difficulties as measured by the Social Communications Disorder Checklist.
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