Fig. 3: Whole-brain group differences in Mu-opioid receptor binding potential.

Significant differences (p_FWE < 0.05) in baseline MOR BP_ND between groups was observed in the left extended amygdala, with individuals in the low-risk for opioid misuse group (PMQ-L) exhibiting lower mu-opioid receptor availability relative to PMQ-H and Control groups.