Fig. 1: Complete workflow detailing the study design and statistical analyses performed: quality control process, association analysis and construction and evaluation of predictive models.

AUC area under the receiver operating characteristic curve, cfNRI the category-free net reclassification improvement, HWE Hardy–Weinberg equilibrium, IDI integrated discrimination improvement, LD linkage disequilibrium, MAF minor allele frequency, MDD major depressive disorder, NRI net reclassification improvement, SNP single nucleotide polymorphism.