Table 2 Brain regions with significant differences in GMV and rs-FC between SAD patients and HCs.

Significant clusters	Peak MNI coordinate of significant clusters			Cluster size (voxels)	Peak T value
Significant clusters	X	Y	Z	Cluster size (voxels)	Peak T value
Between-group differences in GMV
SAD < HCs
Left ParaHIP	−26	−24	−32	153	−4.667
Left putamen	−12	−6	18	820	−4.722
Right putamen	20	10	−10	828	−5.197
Right thalamus	12	−20	16	299	−4.975
SAD > HCs
none
Between-group differences in rs-FC
Seed1: Left putamen
SAD > HCs
Left MTG/STG	−63	−42	−3	173	4.810
SAD < HCs
Left cerebellum	−39	−57	−24	59	−4.999
Seed2: Right putamen
SAD > HCs
Left STG/MTG	−57	-60	27	50	4.593
SAD < HCs
Right cerebellum	18	−90	-33	159	−4.465
Seed3: Right thalamus
SAD > HCs
Left MTG	−48	−63	21	83	4.433
Right MTG/STG	57	−60	21	113	5.027
Right ITG/fusiform gyrus	48	−51	−12	60	4.291
SAD < HCs
Limbic Lobe/Left ACC	−12	24	30	190	−5.227
Left SMA/SFG	−3	−6	72	62	−4.997
Left thalamus	−9	−12	18	143	−5.195
cerebellum	0	−75	−15	126	-4.392

ACC anterior cingulate cortex, GMV gray matter volume, HCs healthy controls, ITG inferior temporal gyrus, MNI Montreal Neurological Institute, MTG middle temporal gyrus, ParaHIP parahippocampus, rs-FC resting-state functional connectivity, SAD social anxiety disorder, SFG superior frontal gyrus, SMA supplementary motor area, STG superior temporal gyrus.
All clusters survived correction for multiple comparisons using Gaussian random field theory with a significance threshold of a voxel-wise value of P < 0.001 and cluster probability of P < 0.05.

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