Table 3 Results of the meta-analysis of resting-state functional connectivity in SUD + BA and controls.

Cluster	Cluster size (mm³)	Brain regions	BA	x	y	z	ALE
*Healthy Control*⁺
1	55,056	L Thalamus		−16	−10	12	0.0112
		R Midbrain		6	−12	−10	0.0103
2	21,672	L Cingulate	24	−8	34	10	0.0101
		R Medial Frontal Gyrus	32	6	32	44	0.0090
*Healthy Control*⁻
1	11,640	L Parietal Lobe	7	−14	−60	60	0.0093
2	10,256	R Cerebellum		0	−76	−24	0.0092
*SUD* + BA⁺
1	31,088	L Amygdala		−22	−6	−14	0.0159
		R Thalamus		10	−20	8	0.0141
		R Midbrain		10	−22	−8	0.0095
2	13,088	R Caudate		10	14	−4	0.0157
		R Putamen		30	−4	−10	0.0099
*SUD* + BA⁻
1	6832	R Posterior Lobe		44	−66	−20	0.0090
2	5536	R Parahippocampal Gyrus		42	−32	−18	0.0090
*SUD* + BA > *Healthy Control*⁺
1	20,864	L Caudate		−12	2	12	0.0209
		L Putamen		−20	16	−6	0.0193
		L Thalamus		−10	−16	14	0.0134
		L Insula	13	−34	12	14	0.0125
2	13,136	R Putamen		26	6	4	0.0244
		R Caudate Body		16	8	4	0.0222
		R Amygdala		26	−8	−28	0.0129
		R Parahippocampal Gyrus	34	16	−4	−18	0.0103
*SUD* + BA < *Healthy Control*⁻
1	9832	R Dorsal Anterior Cingulate	32	8	36	22	0.0242
		R Dorso Medial Frontal Cortex	32	4	30	36	0.0219
		R Dorso Medial Frontal Cortex	6	2	24	44	0.0149

MNI coordinates (x, y, z) of brain regions surviving a cluster-level threshold of p < 0.05 and a cluster forming threshold of p < 0.05 for single studies. Contrast threshold was set to p = 0.05, 5000 permutations, >50 mm³, ALE = Activation Likelihood Estimate; BA = Brodmann Area; ⁺ = Hyperconnectivity; ⁻ = Hypoconnectivity.

Quick links

Search