Table 1 Summary of ERP differences in humans with FXS.
From: EEG as a translational biomarker and outcome measure in fragile X syndrome
Authors | Comparison group (N) | Method | Results |
|---|---|---|---|
Castrén et al. [38] | Fragile X syndrome (5) Neurotypical controls (4) | Auditory oddball | ↑N1 amplitudes ↓N2 amplitudes |
Côté et al. [34] | Fragile X syndrome (14) Tuberous sclerosis complex (9) Down syndrome (19) SYNGAP1-related ID (8) Neurotypical controls (55) | Auditory habituation and oddball | Larger P1-N1 and N1-P2 peak-to-peak values in FXS. Stronger peak-to peak repetition suppression in FXS compared to neurotypical controls. |
Ethridge et al. [31] | Fragile X syndrome (14) Neurotypical controls (15) | Modified auditory gating task | ↓N1 habituation ↓N2 amplitudes |
Ethridge et al. [29] | Fragile X syndrome (38) Neurotypical controls (40) | Auditory habituation task | ↑N1 amplitudes ↑P2 amplitudes However habituation patterns were retained for both N1 and P2 |
Ethridge et al. [46] | Fragile X syndrome (41) Age matched neurotypical controls (27) | Auditory oddball | ↑N1 amplitudes ↑P2 amplitudes |
Knoth et al. [33] | Fragile X syndrome (12) Chronological age-matched neurotypical controls (12) Developmental age-matched neurotypical controls (9) | Auditory and visual evoked paradigm | Auditory: ↑N1 amplitudes ↑P2 amplitudes ↑N2 amplitudes ↑N2 latencies Visual: ↑N70 amplitudes ↑N2 amplitudes |
Rigoulot et al. [35] | Fragile X syndrome (13) Neurotypical controls (24) | Visual habituation | ↑N170 amplitudes to second presentation of stimulus |
Schneider et al. [43] | Fragile X syndrome (12) Neurotypical controls (40) | Auditory oddball | ↑N1 amplitudes ↑P2 amplitudes |
St Clair et al. [28] | Fragile X syndrome (33) Downs syndrome (90) Neurotypical controls (83) | Auditory oddball | ↑N1 amplitudes ↑P2 amplitudes ↓P3 amplitudes |
Van der Molen et al. [32] | Fragile X syndrome (11) Neurotypical controls (22) | Visual and auditory oddball | Findings from both tasks: ↑N1 amplitudes ↑N2b amplitudes ↑N2b latencies ↓P3b amplitudes ↑P3b latencies |
Van der Molen et al. [30] | Fragile X syndrome (16) Neurotypical controls (20) | Auditory oddball | ↑N1 amplitudes ↑N2b amplitudes ↑P2 amplitudes ↑N2b latencies ↓P3a amplitudes ↑P3a latencies |
