Fig. 2: Canonical pathway, protein functional network and diseases analysis for differentially genes in the PFC after LPS injection. | Translational Psychiatry

Fig. 2: Canonical pathway, protein functional network and diseases analysis for differentially genes in the PFC after LPS injection.

From: Nuclear factor of activated T cells 4 in the prefrontal cortex is required for prophylactic actions of (R)-ketamine

Fig. 2

A Adult mice were i.p. injected with LPS (1.0 mg/kg) 6 days after i.p. administration of (R)-ketamine (10 mg/kg) or saline (10 ml/kg). For RNA-sequencing, PFC samples were collected 24 h after injection of LPS. B Top 7 canonical pathways altered in the PFC were identified by Ingenuity Pathway Analysis (IPA). The role of NFAT in regulation of the immune response signaling pathway had the highest inhibition scores (P = 9.85E−05, z-score = –2.236). C IPA constructs identified relationships between the differentially expressed genes and associated disorders. D The most significant molecular network by IPA pathway enrichment analysis. IPA Z-score indicates whether the pathway is predicated to be inhibited (blue) or activated (red). In some cases, activation or inhibition cannot be predicated (gray). The shapes of the proteins imply their molecular classes as outlined in the legend. Solid lines indicate direct interaction whereas dashed line correspond to indirect relationship among the interacting proteins. The arrows indicate modulatory effect of a protein on its interacting proteins.

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