Table 1 Characteristics of the samples used for the Linkage-Disequilibrium SCore regression (LDSC) and GeNetic cOVariance Analyzer (GNOVA) analyses.

Trait/disorder	Author	Year	PMID	Consortium	Ancestry	N	Cases	Controls	N_eff
2hGlu	Saxena et al.	2010	20081857	MAGIC	European	15,234
BMI	Pulit et al.	2019	30239722	GIANT	European	697,734
FPG	Lagou et al.	2021	33402679	MAGIC	European	140,595
FPI	Lagou et al.	2021	33402679	MAGIC	European	98,210
HbA1c	Wheeler et al.	2017	28898252	MAGIC	European	123,665
HOMA-IR	Dupuis et al.	2010	20081858	MAGIC	European	37,037
MetS	Lind	2019	31589552		European	291,107	59,677	231,430	189,772.64
Obesity	Watanabe et al.	2019	31427789		European	244,890	9805	235,085	37,649.69
T2DM	Mahajan et al.	2018	30297969	DIAGRAM	European	898,130	74,124	824,006	272,025.75
ADHD	Demontis et al.	2019	30478444	PGC	European	53,293	19,099	34,194	49,017.41
AD	Wightman et al.	2021	34493870	PGC	European	762,917	86,531	676,386	306,866.18
AN	Watson et al.	2019	31308545	PGC	European	72,517	16,992	55,525	52,041.91
ASD	Grove et al.	2019	30804558	PGC	European	46,350	18,381	27,969	44,366.62
BD	Mullins et al.	2021	34002096	PGC	European	413,466	41,917	371,549	150,669.89
OCD	OCGAS/IOCDF-GC	2018	28761083	OCGAS/IOCDF-GC	European	9725	2688	7037	7780.14
MDD	Wray et al./Howard et al.	2019	29700475/ 29662059	PGC	European	500,199	170,756	329,443	449,855.91
SCZ	Pardinas et al.	2018	29483656	PGC + CLOZUK	European	105,318	40,675	64,643	99,863.42
TS	Yu et al.	2019	30818990	PGC	European	14,307	4819	9488	12,783.30

2hGlu glucose levels 2 h after an oral glucose challenge, BMI body mass index, FPG fasting plasma glucose, FPI fasting plasma insulin, HbA1c glycated haemoglobin, HOMA-IR homeostatic model assessment for insulin resistance, MetS metabolic syndrome, T2DM type 2 diabetes mellitus, ADHD attention-deficit/hyperactivity disorder, AD Alzheimer’s disease, AN anorexia nervosa, ASD autism spectrum disorder, BD bipolar disorder, MDD major depressive disorder, OCD obsessive-compulsive disorder, SCZ schizophrenia, TS Tourette’s syndrome, N total sample size, N_eff effective sample size [N_eff = 4/(1/Cases + 1/Controls)].

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