Table 2 Genetic correlation table reporting the detailed results derived from the bivariate Linkage Disequilibrium SCore regression (LDSC) analyses.

From: Insulinopathies of the brain? Genetic overlap between somatic insulin-related and neuropsychiatric disorders

Trait/disorder

AD

ASD

OCD

ADHD

AN

BD

MDD

SCZ

TS

MetS

0.078 (0.239)

0.115 (0.002)*

−0.315 (3.88 × 10−8)**

0.386 (7.16 × 10−30)**

−0.279 (3.43 × 10−15)**

−0.025 (0.321)

0.177 (1.66 × 10−16)**

−0.090 (1.41 × 10−5)**

−0.026 (0.496)

Obesity

0.085 (0.455)

0.115 (0.072)

−0.379 (3.35 × 10−5)**

0.538 (9.91 × 10−24)**

−0.250 (7.60 × 10−6)**

−0.013 (0.749)

0.235 (5.31 × 10−10)**

−0.087 (0.009)*

0.042 (0.552)

T2DM

0.155 (0.048)*

0.035 (0.403)

−0.172 (3 × 10−4)**

0.328 (3.24 × 10−28)**

−0.209 (6.04 × 10−12)**

−0.037 (0.094)

0.141 (4.65 × 10−11)**

−0.044 (0.016)*

0.013 (0.713)

2hGlu

0.261 (0.103)

0.009 (0.936)

−0.090 (0.591)

−0.004 (0.964)

−0.122 (0.221)

−0.100 (0.180)

0.006 (0.927)

−0.020 (0.743)

−0.034 (0.782)

BMI

0.099 (0.126)

0.043 (0.164)

−0.284 (2.57 × 10−11)**

0.348 (6.59 × 10−49)**

−0.308 (6.38 × 10−38)**

−0.025 (0.167)

0.112 (1.55 × 10−10)**

−0.097 (7.95 × 10−11)**

−0.008 (0.801)

FPG

0.015 (0.828)

−0.043 (0.334)

−0.072 (0.339)

0.123 (6 × 10−4)**

−0.126 (0.005)*

−0.009 (0.777)

0.070 (0.012)*

−0.027 (0.296)

0.089 (0.074)

FPI

0.142 (0.218)

−0.017 (0.797)

−0.108 (0.198)

0.154 (0.005)*

−0.303 (4.17 × 10−7)**

−0.043 (0.319)

0.088 (0.045)*

−0.029 (0.464)

0.089 (0.190)

HbA1C

−0.097 (0.265)

−0.030 (0.619)

0.079 (0.367)

0.124 (0.006)*

−0.155 (0.003)*

−0.032 (0.379)

0.012 (0.722)

−0.009 (0.751)

0.075 (0.225)

HOMA-IR

0.002 (0.985)

0.026 (0.817)

−0.139 (0.255)

0.1313 (0.138)

−0.3029 (1 × 10−4)**

−0.042 (0.505)

0.1044 (0.076)

−0.0278 (0.577)

0.086 (0.390)

  1. Reported values are genetic correlation estimates – rg – (p-values).
  2. AD Alzheimer’s disease, ASD autism spectrum disorders, OCD obsessive-compulsive disorder, ADHD attention-deficit/hyperactivity disorder, AN anorexia nervosa, BD bipolar disorder, MDD major depressive disorder, SCZ schizophrenia, TS Tourette’s syndrome, MetS metabolic syndrome, T2DM type 2 diabetes mellitus, 2hGlu glucose levels 2 h after an oral glucose challenge, BMI body mass index, FPG fasting plasma glucose, FPI fasting plasma insulin, HbA1c glycated hemoglobin, HOMA-IR homeostatic model assessment for insulin resistance.
  3. ** Statistically significant bivariate genetic correlation (p < 6.17 × 10−4).
  4. * Nominally significant bivariate genetic correlation (p < 0.05).
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