Fig. 5: Widespread changes in the global metabolic environment of B6.Del16+/Bdh1-Tfrc mice after HFD challenge.
From: Metabolic effects of the schizophrenia-associated 3q29 deletion
A Comparison of all nominally significant metabolomic features between the HFD-treated male and female datasets. Up arrows indicate metabolites significantly upregulated in B6.Del16+/Bdh1-Tfrc samples, down arrows indicate metabolites significantly downregulated in B6.Del16+/Bdh1-Tfrc samples. Also refer to Supplement. B and C Hierarchical clustering of HFD-treated (B) male (n = 10 WT, 10 B6.Del16+/Bdh1-Tfrc) and C female (n = 10 WT, 10 B6.Del16+/Bdh1-Tfrc) samples using the top 250 ranked metabolomic features. D and E Altered pathways in HFD-treated B6.Del16+/Bdh1-Tfrc mice identified via pathway enrichment analysis of D male and E female datasets. Dashed line denotes statistical significance. Bold text denotes pathways that were identified in both the STD and HFD experiments. F and G Comparison of nominally significant annotated features between STD-treated and HFD-treated (F) male and G female datasets. Up arrows indicate metabolites significantly upregulated in B6.Del16+/Bdh1-Tfrc samples, down arrows indicate metabolites significantly downregulated in B6.Del16+/Bdh1-Tfrc samples. Also refer to Supplement.
