Fig. 1: The virus and bacteria that discriminate DL from HC groups.

LEfSe of bacteria and virus from phylum to species level. Linear discriminant analysis (LDA) combined with effect size measurements revealed a list of features that enable discrimination between the HC and DL groups in the fecal samples. a At the viral level, the DL subjects showed 16 enriched species, mainly belonging to families Myoviridae (7 species) and Siphoviridae (4 species), and 17 depleted species mainly from the families Podoviridae (6 species) and Siphoviridae (6 species). b At the bacterial level, the DL subjects showed 6 enriched species, mainly belonging to family Paraprevotella (3 species), and 8 depleted species mainly from the families Streptococcaceae (3 species) and Gemella (3 species). The discriminative variants (gut virus, bacteria species) were identified based on LDA score >2.5. Sample set: HC, n = 6; DL, n = 6.