Fig. 4: DG-related lipid pathway activity was particularly altered in the PFC of DL macaque. | Translational Psychiatry

Fig. 4: DG-related lipid pathway activity was particularly altered in the PFC of DL macaque.

From: Changes in gut viral and bacterial species correlate with altered 1,2-diacylglyceride levels and structure in the prefrontal cortex in a depression-like non-human primate model

Fig. 4

Analysis of lipid pathway activity showed altered predicted lipid fluxes occurred in brain regions. Calculated Z-scores were chosen to indicate the active/inactive pathways in DL relative to HC, with the positive/negative values. a The PFC of DL macaque showed major altered lipid pathways, which were 3 active pathways LPC-PC-PA-DG-TG, LPC-PC-PA-LPA and LPC-LPA, and 2 inactive pathway DG-PC-LPC, DG-PA-PI-LPI, respectively. Altered lipid pathway activity was calculated by Z-score of each lipid classes in DL (n = 6) relative to HC (n = 6). Red and blue arrows show reactions with positive and negative activity, respectively. Colored circles indicate the fold changes in lipid abundance between 2 groups (−0.47–1.0). Deep arrows indicate the shared lipid flux across the network. b, c The HIP of DL macaque showed minor altered lipid pathways, including active pathway LPC-LPA and inactive pathway LPA-PA-PG-LPG. d molecular geometric alteration of DG related lipid pathways. Blue and yellow backgrounds indicated head groups and hydrophobic part. Dashed frames showed the geometry of lipids molecule, which can be defined as cone (DG, PA, TG), cylinder (PC and PI) and inverted cone (LPI and LPC).

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