Fig. 3: Forest plot and contour enhanced funnel plot showing the meta-analysis results of the association between ADHD in parents and ASD in the offspring (adjusted). | Translational Psychiatry

Fig. 3: Forest plot and contour enhanced funnel plot showing the meta-analysis results of the association between ADHD in parents and ASD in the offspring (adjusted).

From: Parental autoimmune and autoinflammatory disorders as multiple risk factors for common neurodevelopmental disorders in offspring: a systematic review and meta-analysis

Fig. 3

A Mothers, B Fathers. Each square represents individual study effect. Its size represents the study weight in the overall analysis. The black lines on either side of the squares represent the confidence intervals. The diamond at the bottom represents the summary effect with the outer edges representing the confidence intervals. Square or diamond on the right of the central bar (i.e., superior to 1) represents a positive association between paternal AID and ASD in the offspring. To be significant, the confidence interval lines must not cross 1. C Contour enhanced funnel plot for mothers’ analysis. Areas represent studies with p-values larger than 0.10 (white), smaller than 0.05 (light gray), smaller than 0.01 (dark gray), and smaller than 0.001 (light gray outside large triangle).

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