Table 2 Descriptive data for cohort studies included in the meta-analysis.

From: Parental autoimmune and autoinflammatory disorders as multiple risk factors for common neurodevelopmental disorders in offspring: a systematic review and meta-analysis

Author

Year

Country

AID

NDD

N of parents with AID

N of parents with AID and offspring with NDD

N of parents without AID

N of parents without AID and offspring with NDD

Ji

2018

Sweden

T1D

ADHD

6700 + 15,615

NR

993,442 + 1,380,829

NR

Rom

2018

Denmark

RA

ASD

15,615 + 13,556

84

1,380,829 + 1,904,167

18,116

Andersen

2014

Denmark

IBD

ASD

6330 + 6700

62

1,911,393 + 99,442

16,050

Lee

2021

Taiwan

Sjogren, SLE, RA, Systemic sclerosis, Idiopathic inflammatory myositis, T1D, MS, Myasthenia gravis, Psoriasis, IBD, Vasculitis, AS, Behçet

ADHD

1990

117 + 61

706,527

28,092 + 28,148

Lee

2021

Taiwan

Sjogren, SLE, RA, Systemic sclerosis, Idiopathic inflammatory myositis, T1D, MS, Myasthenia gravis, Psoriasis, IBD, Vasculitis, AS, Behçet

ASD

1327

13 + 10

707,190

4493 + 4496

  1. Note that for Lee, we have deliberately shown two different lines because they studied two neurodevelopmental outcomes.
  2. AID autoimmune or inflammatory disorders, NDD neurodevelopmental disorders, T1D type 1 diabetes, RA rheumatoid arthritis, IBD inflammatory bowel disease, ADHD attention deficit/hyperactivity disorders, ASD autism spectrum disorders.