Fig. 1: TrkA-KFG mutant mice have increased CNS levels of TrkA and ChAT.
From: TrkA-cholinergic signaling modulates fear encoding and extinction learning in PTSD-like behavior
Representative western blot images showing TrkA (A) and ChAT (C) protein levels in basal forebrain cholinergic neuron (BFCN) area, striatum, hippocampus (HIP), and cortex. Molecular weight markers in KD are on the right. Note the increased TrkA protein levels in BFCN and striatum of TrkA-KFG mutant mice (A, B). Levels of ChAT protein are increased in BFCN, striatum, and hippocampus but not in cortex (C, D). Actin was used as loading control. Histograms (B, D) show results of quantitative analysis of band intensity in both genotypes. N = 8 per genotype; *p < 0.05 by Student’s t test.
