Fig. 2: CNS TrkA upregulation selectively attenuates fear expression.
From: TrkA-cholinergic signaling modulates fear encoding and extinction learning in PTSD-like behavior
TrkA-KFG mice have specific alterations in contextual fear conditioning. A Graphical representation of the novel object recognition test showing that WT and TrkA-KFG mice spend the same amount of time in exploring the novel versus the familiar object expressed as discrimination ratio (n = 8/group). B Graph showing that the TrkA-KFG mice have reduced freezing response in contextual fear conditioning test (% Freezing 68.63 ± 2.48 in WT and 48.26 ± 3.56 in TrkA-KFG, n = 8/group). C Results from the Morris Water maze test showing that both escape latency (left panel; time to locate the submerged platform) during the acquisition trial for spatial learning as well as the time spent in in the quadrant where the platform was previously located during the probe trial (right panel) for spatial reference memory are similar in WT (n = 15) and TrkA-KFG (n = 14) mice. Statistical analysis by Mann–Whitney test. *p < 0.05.
