Table 1 Modelled proportions of responders defined using different cutoffs in SSRI- and placebo-treated patients; n = 5424 (SSRI) and 2485 (placebo).
Modelled proportions of responders | |||||
|---|---|---|---|---|---|
HDRS-17-sum: remaining proportion of symptoms | SSRI | Placebo | Difference | p | Odds ratio (95% Cl) |
0% | 1.6% | 1.6% | 0.0% | 0.99 | 1.00 (0.62–1.61) |
≤10% | 6.6% | 5.0% | 1.6% | 0.03 | 1.34 (1.03–1.74) |
≤20% | 15.5% | 10.0% | 5.5% | <0.0001 | 1.65 (1.37–1.99) |
≤20% (excluding 15–25%) | 11.7% | 8.2% | 3.5% | 0.0002 | 1.48 (1.20–1.82) |
≤20% (excluding 10–30%) | 9.2% | 6.3% | 2.8% | 0.0006 | 1.49 (1.19–1.87) |
≤30% | 28.7% | 20.0% | 8.7% | <0.0001 | 1.61 (1.39–1.86) |
≤40% | 42.3% | 29.7% | 12.6% | <0.0001 | 1.73 (1.52–1.97) |
≤50% | 54.6% | 42.1% | 12.5% | <0.0001 | 1.65 (1.47–1.87) |
≤50% (excluding 45–55%) | 52.5% | 39.1% | 13.4% | <0.0001 | 1.72 (1.52–1.95) |
≤50% (excluding 40–60%) | 51.9% | 37.9% | 14.0% | <0.0001 | 1.77 (1.55–2.01) |
≤60% | 65.7% | 52.4% | 13.3% | <0.0001 | 1.74 (1.55–1.96) |
≤70% | 74.8% | 63.4% | 11.5% | <0.0001 | 1.72 (1.52–1.94) |
≤80% | 82.7% | 72.2% | 10.5% | <0.0001 | 1.84 (1.61–2.11) |
≤90% | 89.3% | 81.2% | 8.1% | <0.0001 | 1.93 (1.65–2.26) |
≤100% | 95.1% | 91.1% | 4.0% | <0.0001 | 1.91 (1.54–2.38) |
HDRS-6-sum: remaining proportion of symptoms | SSRI | Placebo | Difference | p | Odds ratio (95% Cl) |
0% | 6.7% | 4.6% | 2.2% | 0.003 | 1.50 (1.15–1.97) |
≤10% | 13.5% | 7.9% | 5.6% | <0.0001 | 1.82 (1.48–2.23) |
≤20% | 19.1% | 11.5% | 7.6% | <0.0001 | 1.82 (1.54–2.16) |
≤20% (excluding 15–25%) | 15.8% | 9.3% | 6.5% | <0.0001 | 1.84 (1.52–2.22) |
≤20% (excluding 10–30%) | 14.0% | 8.3% | 5.6% | <0.0001 | 1.78 (1.46–2.17) |
≤30% | 30.7% | 19.2% | 11.5% | <0.0001 | 1.86 (1.61–2.15) |
≤40% | 43.2% | 28.9% | 14.3% | <0.0001 | 1.87 (1.65–2.13) |
≤50% | 58.3% | 42.1% | 16.3% | <0.0001 | 1.93 (1.71–2.18) |
≤50% (excluding 45–55%) | 54.5% | 38.2% | 16.3% | <0.0001 | 1.94 (1.71–2.20) |
≤50% (excluding 40–60%) | 54.2% | 37.3% | 16.9% | <0.0001 | 1.99 (1.75–2.26) |
≤60% | 66.7% | 50.4% | 16.3% | <0.0001 | 1.97 (1.75–2.22) |
≤70% | 74.9% | 59.0% | 15.9% | <0.0001 | 2.07 (1.83–2.34) |
≤80% | 82.1% | 67.4% | 14.8% | <0.0001 | 2.22 (1.95–2.54) |
≤90% | 88.0% | 76.5% | 11.5% | <0.0001 | 2.26 (1.95–2.61) |
≤100% | 96.1% | 92.5% | 3.5% | <0.0001 | 1.97 (1.56–2.49) |
Depressed mood: change from baseline | SSRI | Placebo | Difference | p | Odds ratio (95% Cl) |
−4 | 1.6%* | 0.6%* | 1.0%* | 0.0002* | 2.72 (1.57–4.70)* |
≤−3 | 14.9% | 7.8% | 7.2% | <0.0001 | 2.08 (1.75–2.47) |
≤−2 | 55.8% | 39.1% | 16.6% | <0.0001 | 1.96 (1.73–2.22) |
≤−1 | 82.7% | 69.1% | 13.6% | <0.001 | 2.13 (1.87–2.44) |
≤0 | 98.7% | 96.7% | 2.1% | <0.0001 | 2.73 (2.00–3.73) |
