Table 2 Modelled proportions of responders defined using different cutoffs with respect to endpoint scores in SSRI- and placebo-treated patients; n = 5424 (SSRI) and 2485 (placebo).
Modelled proportions of responders | |||||
|---|---|---|---|---|---|
HDRS-17 endpoint score | SSRI | Placebo | Difference | p | Odds ratio (95% Cl) |
0 p | 1.3%* | 1.3%* | 0.0%* | 0.87* | 1.04 (0.68–1.58)* |
≤1 p | 3.8% | 3.2% | 0.7% | 0.25 | 1.22 (0.87–1.71) |
≤2 p | 6.9% | 5.0% | 1.9% | 0.01 | 1.40 (1.07–1.82) |
≤3 p | 10.9% | 7.4% | 3.5% | 0.0002 | 1.53 (1.26–1.90) |
≤4 p | 14.6% | 10.4% | 4.2% | <0.0001 | 1.47 (1.22–1.78) |
≤5 p | 20.5% | 14.6% | 5.9% | <0.0001 | 1.51 (1.28–1.78) |
≤6 p | 26.3% | 17.6% | 8.6% | <0.0001 | 1.66 (1.43–1.94) |
≤7 p | 33.1% | 22.3% | 10.8% | <0.0001 | 1.72 (1.50–1.99) |
≤7 p (excluding 6–8 p) | 24.9% | 17.1% | 7.9% | <0.0001 | 1.61 (1.38–1.89) |
≤7 p (excluding 5–9 p) | 22.4% | 15.3% | 7.0% | <0.0001 | 1.59 (1.35–1.88) |
≤8 p | 37.8% | 25.5% | 12.2% | <0.0001 | 1.77 (1.55–2.03) |
≤9 p | 43.2% | 31.6% | 11.6% | <0.0001 | 1.65 (1.45–1.87) |
≤10 p | 48.8% | 36.6% | 12.2% | <0.0001 | 1.65 (1.46–1.87) |
HDRS-6 endpoint score | SSRI | Placebo | Difference | p | Odds ratio (95% Cl) |
0 p | 6.7% | 4.6% | 2.2% | 0.003 | 1.51 (1.15–1.98) |
≤1 p | 14.0% | 7.9% | 6.1% | <0.0001 | 1.90 (1.55–2.34) |
≤2 p | 19.8% | 11.8% | 8.0% | <0.0001 | 1.85 (1.56–2.19) |
≤3 p | 29.6% | 18.5% | 11.2% | <0.0001 | 1.86 (1.60–2.16) |
≤4 p | 40.0% | 26.3% | 13.8% | <0.0001 | 1.88 (1.64–2.15) |
≤4 p (excluding 3–5 p) | 30.8% | 18.5% | 12.3% | <0.0001 | 1.96 (1.68–2.29) |
≤4 p (excluding 2–6 p) | 27.4% | 16.2% | 11.3% | <0.0001 | 1.96 (1.66–2.31) |
≤5 p | 49.7% | 35.2% | 14.5% | <0.0001 | 1.82 (1.60–2.06) |
≤6 p | 59.2% | 42.4% | 16.8% | <0.0001 | 1.97 (1.74–2.23) |
≤7 p | 67.4% | 51.1% | 16.3% | <0.0001 | 1.98 (1.74–2.24) |
≤8 p | 75.3% | 60.2% | 15.0% | <0.0001 | 2.01 (1.76–2.29) |
≤9 p | 82.5% | 68.0% | 14.5% | <0.0001 | 2.21 (1.92–2.55) |
≤10 p | 87.8% | 76.2% | 11.6% | <0.0001 | 2.25 (1.92–2.63) |
Depressed mood endpoint score | SSRI | Placebo | Difference | p | Odds ratio (95% Cl) |
0 p | 27.1% | 15.7% | 11.4% | <0.0001 | 2.00 (1.70–2.34) |
≤1 p | 66.4% | 48.4% | 18.0% | <0.0001 | 2.10 (1.86–2.39) |
≤2 p | 89.3% | 77.6% | 11.7% | <0.0001 | 2.41 (2.05–2.82) |
≤3 p | 99.6% | 99.0% | 0.6% | 0.04 | 2.27 (1.05–4.92) |
