Fig. 3: Violin plots displaying the distribution in symptom severity while on clozapine by polygenic risk score subgroups. | Translational Psychiatry

Fig. 3: Violin plots displaying the distribution in symptom severity while on clozapine by polygenic risk score subgroups.

From: Genome-wide association analyses of symptom severity among clozapine-treated patients with schizophrenia spectrum disorders

Fig. 3

A, B Violin plots of schizophrenia-PRS (PRS-SCZ) comparison for binary outcome, and cross-disorder-PRS (PRS-CDG) tertile comparison for quantitative outcome. For both analyses the best fitting p was used. The dashed line illustrates the mean PRS-SCZ (A) and the mean residual CGI-S score (B) in all participants. Differences were determined by linear regression of quantitative outcome on PRS tertile and using a T-test for binary outcome, corrected for sex, age, and 10 PCs (Supplementary Methods). **p < 5.0 × 10−3. ns nonsignificant.

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