Table 1 Amino acid sequences of synthetic peptides derived from the transmembrane domains of OX1R and 5-HT1AR.

From: Disruption of 5-hydroxytryptamine 1A receptor and orexin receptor 1 heterodimer formation affects novel G protein-dependent signaling pathways and has antidepressant effects in vivo

OX1R-TM

 

Molecular weight (Da)

TM1

WVLIAAYVAVFLIALVGNTLVYGRKKRRQRRR

3787.61

TM4

YGRKKRRQRRRARGSILGIWAVSLAIMVPQAAV

3765.54

TM5

IYHSCFFIVTYLAPLGLMAMAYYGRKKRRQRRR

4066.88

TM6

YGRKKRRQRRR MLMVVLLVFALCYLPISVLNVLK

4134.23

TM6-L309A

YGRKKRRQRRR MLMVVLLVFAACYLPISVLNVLK

4092.15

5-HT1AR-TM

 

Molecular weight (Da)

TM3

LFIALDVLCCTSSILHLCAIALYGRKKRRQRRR

3874.75

TM4

YGRKKRRQRRRRRAAALISLTWLIGFLISIPPMLGWRTP

4692.70

TM5

DHGYTIYSTFGAFYIPLLLMLVLYGRKKRRQRRR

4566.41

TM6

YGRKKRRQRRRVKTLGIIMGTFILCWLPFFIVAL

4138.16

TM4-R151A

YGRKKRRQRRRARAAALISLTWLIGFLISIPPMLGWRTP

4607.40

TM6-M351A

YGRKKRRQRRR VKTLGIIAGTFILCWLPFFIVAL

4078.04

TM6-L356A

YGRKKRRQRRR VKTLGIIMGTFIACWLPFFIVAL

4096.08

  1. Italic letter indicates replacement of the original amino acid by alanine.
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