Fig. 3: Association of Big Five Polygenic Scores (PGS) with Borderline Personality Disorder case-control status. | Translational Psychiatry

Fig. 3: Association of Big Five Polygenic Scores (PGS) with Borderline Personality Disorder case-control status.

From: Borderline personality disorder and the big five: molecular genetic analyses indicate shared genetic architecture with neuroticism and openness

Fig. 3

Left panels: Proportion of explained variance in case-control status (Nagelkerke R²) depicted for the ten tested p value thresholds (PT). Right panels: Odds Ratio for BPD by PGS quintile, with decile 1 as reference. Regressions were computed with the first 10 ancestry principle components to adjust for population stratification. * p < 0.05; ** p < 0.005 (0.05/10 tested p-value thresholds per PGS); *** p < 0.001 (0.05/10 tested p-value thresholds /5 personality traits); 4* p < 1*10−4; 5* p < 1*10−5; 6* p < 1*10−8; 7* p < 1*10−12. Neuroticism-PGS was based on Nagel et al. [23], the other BIG-5 personality traits PGS were based on Lo et al. [22].

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