Table 1 Top ten significantly enriched phenotypes preceding schizophrenia diagnoses in adolescents and young adults aged between 15 and 29 (number of schizophrenia patients in this age group = 13,828).
From: Large-scale real-world data analysis identifies comorbidity patterns in schizophrenia
Phecode | Phecode description | Number of schizophrenia patients | Number of non-schizophrenic participants | Odds ratio | 95% Confidence interval | P-value |
|---|---|---|---|---|---|---|
297.1 | Suicidal ideation | 775 | 16 | 51.2 | (31.3, 90.2) | 3 × 10−210 |
296.1 | Bipolar | 2476 | 83 | 36.1 | (29, 45.5) | 2 × 10−308 |
301.2 | Antisocial/borderline personality disorder | 200 | 11 | 18.4 | (10.1, 37.5) | 2 × 10−46 |
316 | Substance addiction and disorders | 2635 | 182 | 17.6 | (15.1, 20.7) | 2 × 10−308 |
296 | Mood disorders | 1369 | 93 | 16.2 | (13.1, 20.3) | 5 × 10−305 |
300.9 | Posttraumatic stress disorder | 636 | 41 | 16.2 | (11.8, 22.8) | 5 × 10−141 |
300 | Anxiety, phobic and dissociative disorders | 232 | 16 | 14.7 | (8.9, 26.2) | 1 × 10−50 |
317 | Alcohol-related disorders | 517 | 39 | 13.7 | (9.9, 19.6) | 2 × 10−109 |
296.22 | Major depressive disorder | 3406 | 329 | 13.4 | (11.9, 15.1) | 2 × 10−308 |
301 | Personality disorders | 139 | 11 | 12.8 | (6.9, 26.1) | 2 × 10−29 |
