Table 3 Significantly differentially expressed genes between MDD-S and MDD-NS in the DLPFC (p ≤ 0.05), corresponding q-value after FDR correction (q ≤ 0.1 are in bold), and fold change in MDD-S relative to MDD-NS.

Gene	Mean (Control)	Mean (MDD-NS)	Mean (MDD-S)	p (MDD-S vs. MDD-NS)	q value (MDD-S vs. MDD-NS)	FC (MDD-S vs. MDD-NS)	FC direction
SAT1_all	11.418	11.521	11.156	0.0001	0.005	−1.316	DOWN
MT3	14.289	14.453	14.185	0.0002	0.008	−1.220	DOWN
TERC	10.105	10.241	9.898	0.001	0.004	−1.202	DOWN
HSD11B2	4.621	5.286	4.598	0.002	0.004	−1.450	DOWN
FKBP5	9.071	10.055	9.085	0.002	0.003	−1.592	DOWN
FGF2	10.361	10.519	10.085	0.002	0.027	−1.384	DOWN
MAOA	9.560	9.644	9.379	0.003	0.013	−1.205	DOWN
PAOX	6.324	6.440	6.219	0.003	0.031	−1.193	DOWN
MT2A	10.793	11.094	10.515	0.003	0.010	−1.432	DOWN
SAT1-002	5.685	6.021	5.673	0.004	0.031	−1.279	DOWN
AGMAT	6.415	6.128	6.430	0.004	0.031	1.244	UP
MT1A	6.737	7.591	6.228	0.004	0.017	−2.404	DOWN
ARNTL	10.396	10.430	10.252	0.008	0.019	−1.131	DOWN
SOX9	10.498	10.610	10.083	0.009	0.027	−1.425	DOWN
NFE2L2	10.170	10.232	9.991	0.009	0.049	−1.203	DOWN
ODC1	9.388	9.553	9.436	0.011	0.150	−1.107	DOWN
MT1X	9.602	10.414	9.627	0.012	0.042	−1.693	DOWN
PPARA	8.204	8.287	8.065	0.013	0.075	−1.187	DOWN
CD19	4.369	4.497	4.084	0.015	0.019	−1.311	DOWN
TERF1	9.958	9.998	9.908	0.015	0.150	−1.086	DOWN
RBFOX3	10.787	10.668	10.810	0.018	0.013	1.073	UP
CRH	8.472	7.732	8.314	0.019	0.031	1.352	UP
PER3	10.250	10.119	10.333	0.022	0.031	1.132	UP
HTR1A	6.866	7.003	6.768	0.023	0.120	−1.201	DOWN
SAT1-001	11.524	11.594	11.366	0.024	0.150	−1.189	DOWN
GRIN2C	9.267	9.268	9.072	0.030	0.180	−1.167	DOWN
OAZ2	11.797	11.874	11.800	0.043	0.226	−1.078	DOWN
SRM	10.288	10.346	10.290	0.045	0.223	−1.063	DOWN

DLPFC dorsolateral prefrontal cortex, MDD-S major depressive disorder—suicide, MDD-NS major depressive disorder—non-suicide, FC fold-change, FDR false discovery rate.

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