Fig. 3: Identification of differentially A-to-I RNA edited sites between healthy controls and depressed patients using RNA-Seq data from human blood.
From: A game changer for bipolar disorder diagnosis using RNA editing-based biomarkers
A Volcano plot of differentially edited sites between healthy controls and depressed patients. The volcano plot shows the upregulated and downregulated sites differentially edited between depressed patients healthy controls. For each plot, the x-axis represents the log2(Fold Change) (FC), and the y-axis represents -log10(p values). Editing sites with a p value of < 0.05 were assigned as differentially edited and are indicated in green. Significant editing sites of selected genes (see Table 2) are labeled in black. B: Heatmap of MeSH class associated with the 7 genes identified by RNAseq annotated by the DisGeNET database. All identified genes have been analyzed and their relationships with mental disorders, behavior and behavior mechanisms, nervous system diseases and immune system diseases MeSH categories have been calculated with DisGeNET database. The darker the heatmap, the stronger the association.
