Fig. 4: Comparison of the differentially expressed modules in the PFC of BPD to those from Torin1 treated neurons. | Translational Psychiatry

Fig. 4: Comparison of the differentially expressed modules in the PFC of BPD to those from Torin1 treated neurons.

From: Differential expression of gene co-expression networks related to the mTOR signaling pathway in bipolar disorder

Fig. 4

Pairwise comparisons of the modules differentially expressed in BPD and the differentially expressed modules in Torin1-treated neurons (A). The color code of the heatmap encodes −log (P-value). The P-values were calculated by permutation test for the overlap of the two modules. The numbers in the heatmap indicate gene counts in the intersection of two modules. Venn diagram shows the number of common and unique genes between the PFC_M23 and the Torin1_M6 module (B). KEGG pathways significantly enriched in the genes common to both co-expression modules (C) and visualization of the network connections of the common genes between the two modules using Cytoscape [25] (D). The hub genes are larger circles in the network. Genes related to mTOR signaling pathway are in red and genes related to synaptic vesicle cycle are in blue.

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