Table 3 Significant clusters and within-cluster peaks identified in global ALE analyses of both pain and depression as primary condition, presented separately for the original sample of 68 studies.

From: Neural correlates of co-occurring pain and depression: an activation-likelihood estimation (ALE) meta-analysis and systematic review

Label

Cluster size mm3

Coordinates (MNI)

N foci contrib.

x

y

z

Global analysis for pain as primary condition (76 foci, 586 subjects)

Right parahippocampal gyrus/amygdala

1136

20

−2

−18

5

Global analysis for depression as primary condition (39 foci, 119 subjects)

Left superior frontal gyrus

456

−24

22

44

2

Left thalamusa

424

−16

−10

10

2

  1. aThe left thalamus cluster was not observed when 2 additional studies identified in the 2020–2021 search were added.
Back to article page