Fig. 4: DCM analysis of the prefrontal-amygdala network. | Translational Psychiatry

Fig. 4: DCM analysis of the prefrontal-amygdala network.

From: Deficient prefrontal-amygdalar connectivity underlies inefficient face processing in adolescent major depressive disorder

Fig. 4

A The common effect represents the overall model structure for the baseline (neutral faces) across all participants. B Group differences were primarily found in the bidirectional cortical pathway FFA-LPFC-sgACC for the average connectivity across conditions. In addition, connectivity between sgACC and the amygdala was decreased in patients. C, D Efferent connectivity from the amygdala was modulated by positive (C) and negative (D) valence. In addition, processing of positive valence was associated with altered LPFC—amygdala connectivity and the LPFC—sgACC—amygdala pathway. Detailed results are reported in Table S7. AMY amygdala, FFA fusiform face area, HC healthy controls, LPFC lateral prefrontal cortex, MDD major depressive disorder, sgACC subgenual anterior cingulate cortex.

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