Table 2 Urinary excretion of markers of DNA and RNA damage from oxidation, 8-oxodG and 8-oxoGuo (nmol/mmol creatinine), respectively, in the full control population, the age- and sex-matched control population, and in one hundred antidepressant drug-free patients with unipolar depression pre- and post-treatment with a serotonergic antidepressant (escitalopram/duloxetine) for 8 weeks.

From: Systemic DNA and RNA damage from oxidation after serotonergic treatment of unipolar depression

 

Controls, full (N = 856)

Controls, matched (N = 67)

Patients (baseline) (N = 100)

Patients (week 8) (N = 82)

8-oxodG

1.6 (0.7)

1.6 (0.8)

1.7 (0.7)

1.2 (0.5)*,**

8-oxoGuo

1.9 (0.6)

1.8 (0.5)

1.6 (0.4)*

1.4 (0.3)*,**

  1. Data are showed as means and standard deviations and were analyzed with independent or paired t-tests, as appropriate.
  2. *Significantly different from both control groups (p < 0.001).
  3. **Significantly different from pre-treatment (p < 0.001).
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