Fig. 5: Effect of the NHT components on 5-HT1A activity in Xenopus oocytes.
From: Anxiolytic and antidepressants’ effect of Crataegus pinnatifida (Shan Zha): biochemical mechanisms
Representative recordings of the effect of 5-HT (A) and Shan Zha (B) on 5-HT1A-mediated GIRK currents. Spiperone (spip) was used to specifically block the receptor-mediated currents. C Cumulative results of the activation of the 5-HT1A receptor by the different components, normalized to the response evoked by 5-HT on the same oocyte. Results are mean ± SEM from 4 to 12 oocytes for each component. Shan Zha, Fu Xiao Mai, and Baihe activated the receptor significantly better than escitalopram (p < 0.005).
