Table 3 Results of parallel four-mediator model in the discovery sample (UCC).

Regressions	Unstandardized B estimate (95% CI)	Standardized estimate	p value
Direct effects
Outcome model: PLE (R² = 0.424)
SZ-PRS	0.187 (0.035; 0.339)	0.072	0.016
CM	0.223 (0.117; 0.328)	0.143	<0.001
Cannabis use	2.78 (0.538; 5.02)	0.094	0.015
Neuroticism	0.302 (0.265; 0.338)	0.541	<0.001
Nicotine	2.57 (0.168; 4.61)	0.082	0.035
Mediator model: CM (R² = 0.011)
SZ-PRS	0.172 (0.036; 0.307)	0.103	0.013
Mediator model: cannabis use (R² = 0.021)
SZ-PRS	0.013 (0.006; 0.019)	0.144	<0.001
Mediator model: neuroticism (R² = 0.003)
SZ-PRS	0.247 (−0.120; 0.614)	0.053	0.186
Mediator model: nicotine (R² = 0.018)
SZ-PRS	0.012 (0.006; 0.018)	0.136	<0.001
Covariances
CM—cannabis use	0.389 (0.065; 0.713)	0.101	0.018
CM—neuroticism	80.89 (62.81; 98.97)	0.390	<0.001
CM—nicotine	0.149 (−0.183; 0.481)	0.038	0.379
Cannabis—nicotine	0.129 (0.112; 0.146)	0.628	<0.001
Cannabis—neuroticism	0.080 (−0.791; 0.951)	0.007	0.858
Neuroticism—nicotine	0.472 (−0.423; 1.37)	0.043	0.301
Indirect effects (proportion mediated)
CM (10.5%)	0.038 (0.003; 0.073)	0.015	0.033
Cannabis (9.6%)	0.035 (0.002; 0.068)	0.013	0.038
Neuroticism (20.7%)	0.075 (−0.036; 0.186)	0.029	0.188
Nicotine (8.0%)	0.029 (−0.002; 0.059)	0.011	0.065
Sum	0.176 (0.045; 0.308)	0.068	0.009
Total effect	0.363 (0.181; 0.545)	0.140	<0.001

95% CI 95% bias-corrected bootstrap confidence interval, PLE psychotic-like experiences, CM childhood maltreatment, SZ-PRS schizophrenia polygenic risk score at p value threshold 0.5.

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