Fig. 3: A schematic depicting utilization of human iPSC-derived neurons for modeling dysfunction of NMDARs associated with neuropsychiatric disorders. | Translational Psychiatry

Fig. 3: A schematic depicting utilization of human iPSC-derived neurons for modeling dysfunction of NMDARs associated with neuropsychiatric disorders.

From: Targeting NMDA receptors in neuropsychiatric disorders by drug screening on human neurons derived from pluripotent stem cells

Fig. 3

Human neurons differentiated from iPSCs from individuals with neuropsychiatric disorders (NPD), with or without an NPC stage, are used for translational screening platform and for the discovery and development of drugs targeting NMDARs. NMDA-evoked currents and synaptic NMDAR currents are investigated in human iPSC-derived neurons from unaffected controls and individuals with neuropsychiatric disorders.

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