Table 2 Associations between AUD and PRSgene, PRSintergenic, and PRSall in AA and EA.

From: Gene-based polygenic risk scores analysis of alcohol use disorder in African Americans

  

PRSgene

PRSintergenic

PRSall

Population

Target dataset

Beta

SE

P-value

# Variants

Beta

SE

P-value

# Variants

Beta

SE

P-value

# Variants

AA

Alla

0.17

0.03

3.55E−08

858

0.03

0.03

0.32

675

0.12

0.03

9.42E−05

1,126,428

COGA

0.15

0.04

9.67E−04

858

0.02

0.04

0.61

675

0.06

0.04

0.16

1,126,428

SAGE

0.18

0.07

6.27E−03

858

0.12

0.07

0.10

675

0.18

0.07

0.01

1,126,428

YalePenn

0.21

0.05

7.61E−05

858

−0.02

0.06

0.76

675

0.17

0.06

7.28E−03

1,126,428

EA

Indiana Biobank

0.11

0.05

0.02

847

0.02

0.05

0.59

666

0.34

0.05

2.35E−21

1,061,130

  1. Significant P-values are in bold.
  2. PRSgene PRS calculated using concordant variants located in genes associated with AUD in both AA and EA, PRSintergenic PRS calculated using concordant variants located outside genes associated with AUD in both AA and EA, PRSall PRS calculated using all variants.
  3. aCOGA, SAGE, and YalePenn combined.
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