Fig. 3: Sex differences in the effects of psychiatric disorder PRSs on the brain. | Translational Psychiatry

Fig. 3: Sex differences in the effects of psychiatric disorder PRSs on the brain.

From: Sex-specific genetic association between psychiatric disorders and cognition, behavior and brain imaging in children and adults

Fig. 3

The IDPs (imaging-derived phenotypes) that was significantly associated with psychiatric disorders PRSs and the association was different between sexes, referred to as sex-specific IDPs. A The x-axis shows the number of sex-specific IDPs, indicating the psychiatric disorders and the corresponding sex of stronger association (e.g., UKB_SCZ_m represents the genetic association between SCZ PRSs and brain is significantly stronger in males than females in the UKB). Different colors represent different brain imaging modalities. Orange bins and instance counts from the histogram indicate the sex-specific rsfMRI IDPs. Purple indicates the sex-specific DTI IDPs. Green indicates the sex-specific sMRI IDPs. B The sex-specific brain volume that more associated in females. C, D The sex-specific white matter tracts, D blue indicates the sex-specific white matter tracts of males. scz schizophrenia.

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