Table 3 Different types of effects present in mediation analysis.

From: Sex-specific genetic association between psychiatric disorders and cognition, behavior and brain imaging in children and adults

ab

c′

R2(ab)

R2(c′)

 

Numbers

M

F

M

F

Zero

Zero

–

–

 

F > M

Other mediators

20

Zero

–

–

–

F > M

F > M

Other mediators

13

–

–

–

–

F > M / NS

F > M

Other mediators

4

–

Zero

–

–

M > F

F > M

Cancel out

3

Zero

+

–

–

F > M

F > M

Cancel out

2

+

+

–

–

NS

F > M

Other mediators / Cancel out

2

  1. ab the third variable effect; c′ direct effect; R2(ab) the sex difference of the partial R2 of the indirect effect of SCZ PRS on cognitive function; R2(c′) the sex difference of the partial R2 of the direct effect of SCZ PRS on cognition. Numbers the number of different conditions in the mediation analysis. F female; M male; − negative effects; + positive effects; Zero, NS nonsignificant. Significance was set at FDR < 0.05.