Fig. 3: iuGC exposure hampers neuronal basal activity of ACC and NAc. | Translational Psychiatry

Fig. 3: iuGC exposure hampers neuronal basal activity of ACC and NAc.

From: Prenatal dexamethasone exposure alters effort decision making and triggers nucleus accumbens and anterior cingulate cortex functional changes in male rats

Fig. 3

A Schematic representation of electrophysiological recordings of ACC, NAc, and VTA. B ACC neurons were separated according to firing rate and waveform characteristics: putative glutamatergic neurons; NAc neurons were separated according to firing rate and waveform characteristics putative medium spiny neurons (pMSNs); VTA neurons were classified as: putative dopaminergic neurons or putative GABAergic neurons. C The basal firing rate of the ACC is significantly different between groups, with iuGC rats presenting a hyperactivation of putative glutamatergic neurons. nCTR = 4 animals/90 cells (12–32 cells/animal); niuGC = 4 animals/58 cells (13–18 cells/animal). D iuGC group has an hyperactivation of putative MSNs of the NAc; nCTR = 4 animals/68 cells (8–16 cells/animal); niuGC = 5 animals/67 cells (6–20 cells/animal). The basal activity of the VTA of E putative GABAergic (nCTR = 4 animals/56 cells (2–12 cells/animal); niuGC = 4 animals/54 cells (2–15 cells/animal)) and F putative dopaminergic neurons (nCTR = 5 animals/36 cells (2–12 cells/animal); niuGC = 5 animals/55 cells (2–12 cells/animal)) is similar between groups. Error bars denote SEM. *p ≤ 0.05; **p ≤ 0.01.

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