Fig. 4: Distinct NAc and VTA neuronal response to ACC optogenetic stimulation in iuGC animals. | Translational Psychiatry

Fig. 4: Distinct NAc and VTA neuronal response to ACC optogenetic stimulation in iuGC animals.

From: Prenatal dexamethasone exposure alters effort decision making and triggers nucleus accumbens and anterior cingulate cortex functional changes in male rats

Fig. 4

A Strategy used for optogenetic activation of ACC projecting neurons in the NAc and VTA. Response of NAc neurons to ACC optogenetic stimulation in B CTR rats C and iuGC rats (nCTR = 5 animals/48 cells (10–20 cells/animal); niuGC = 5 animals/72 cells (12–22 cells/animal). D Change in neuronal activity of NAC neurons upon ACC optical activation. E The NAc of iuGC rats present impaired magnitude of response, to ACC stimulation. F Strategy used for optogenetic activation of ACC projecting neurons in the VTA. Response of VTA pDopaminergic (nCTR = 4 animals/20 cells (2–10 cells/animal); niuGC = 4 animals/36 cells (3–10 cells/animal) and pGABAergic neurons (nCTR = 4 animals/23 cells (4–12 cells/animal); niuGC = 4 animals/32 cells (1–7 cells/animal) to ACC optogenetic stimulation in (G, I) CTR rats (H, J) and iuGC rats, respectively. Optical stimulation of ACC terminals in the VTA does not alter firing rate of K pDopaminergic neurons or M pGABAergic neurons. The magnitude of response of L pDopaminergic neurons or N pGABAergic neurons is similar between groups. Error bars denote SEM. *p ≤ 0.05; **p ≤ 0.01.

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