Fig. 3: Speculative “ready-set-go” model of MYT TFs during neuronal differentiation.
From: MYT1L in the making: emerging insights on functions of a neurodevelopmental disorder gene
A “Ready” phase: initial expression of MYT1 during early neurodevelopment represses non-neuronal and neuronal maturation gene expression programs. B “Set” phase: MYT1 expression fades and is replaced by MYT1L and is still net repressive to prevent maturation gene expression. This ensures maintenance of the progenitor pool. C “Go” phase: MYT1L, due to possible interactions with cofactors, postransciptional modifications, or increased expression levels activates the expression of neuronal maturation genes. Figure created with BioRender.com.
