Fig. 2: Comparison of PRS between the ISHDSF diagnostic categories and sporadic cases, versus population controls.

All analyses follow the hypothesis that ISHDSF members and sporadic cases have a higher PRS compared to population controls. All PRS have been normalized using Z-score standardization prior to obtaining odds ratios. The plots show odds ratios (OR, filled circles) with 95% confidence intervals (CI) for each category compared to population controls. X axis represents the odds ratios. Left side of Y axis represents each of the categories used for comparison versus population controls. Right side of the Y axis represents the p-values after multiple testing correction.