Table 1 Diagnostic categories present in the ISHDSF sample.

From: Evaluating the role of common risk variation in the recurrence risk of schizophrenia in multiplex schizophrenia families

Irish study of high-density schizophrenia families (ISHDSF)

           

Very Broad

 
        

Broad

     
   

Intermediate

          
  

Narrow

              

Category

Description

Schizophrenia

Schizoaffective disorder1

Psychosis NOS

Schizophreniform disorder

Delusional disorder

Schizotypal personality disorder

Avoidant personality disorder

Schizoid personality disorder

Paranoid personality disorder

Bipolar disorder

Major depressive disorder

Alcohol dependence/abuse

Generalized anxiety disorder

Panic disorder

Othera

Unaffected relatives2

Narrow (N = 469)

Narrow Schizophrenia spectrum

409

60

              

Intermediate (N = 112)

Intermediate Schizophrenia spectrum

 

30

34

10

7

31

          

Broad (N = 52)

Disorders significantly aggregating in the relatives of probands

      

9

2

2

17

22

     

Very Broad (N = 140)

Any other psychiatric disorders in the relatives of probands

         

4

80

27

21

6

2

 

Unaffected (N = 232)

Unaffected relatives of probands

               

232

  

409

90

34

10

7

31

9

2

2

21

102

27

21

6

2

232

  1. The concentric diagnostic hierarchy of the ISHDSF contains four case definitions: narrow, Intermediate, Broad and Very Broad spectrums. These case definitions in the ISHDSF reflect core and periphery of the psychosis spectrum based on previous genetic epidemiology work referenced in the methods section. A visual representation is provided in Supplementary Fig. 4.
  2. 1Poor-outcome and good-outcome schizoaffective cases are represented in narrow and intermediate diagnostic category respectively.
  3. 2There are four individuals with intellectual disability in the unaffected relatives category.
  4. aOther diagnoses include Anorexia Nervosa (1) and Cyclothymia (1) in the very-broad diagnostic category.
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