Table 2 Descriptive and Model-estimated Statistics for Primary Outcome (CAPS-IV, past week): Exposure Therapy and Augmentation Over Time by Baseline MDD.

From: Enhancing exposure therapy for posttraumatic stress disorder (PTSD): a randomized clinical trial of virtual reality and imaginal exposure with a cognitive enhancer

	Exposure Therapy (VRE vs. PE)						Augmentation (DCS vs. Placebo)
	VRE n = 97			PE n = 95			DCS n = 95			Placebo n = 97
CAPS-IV, past week	Descriptive Statistics						Descriptive Statistics
Overall	N	M	SD	N	M	SD	N	M	SD	N	M	SD
Baseline	97	73.13	19.48	95	72.94	19.56	95	73.42	19.31	97	72.66	19.72
After session 4	81	76.85	19.88	68	71.65	24.48	73	77.04	21.39	76	72.01	22.77
After session 6	73	62.97	23.73	64	64.80	26.78	70	65.51	25.31	67	62.06	24.99
Posttreatment	69	52.42	26.55	61	50.61	25.22	69	54.20	26.72	61	48.59	24.71
3-month Follow-up	64	49.03	26.12	52	50.35	28.93	62	53.00	27.55	54	45.74	26.71
MDD
Baseline	54	78.44	17.20	50	81.90	17.28	52	81.54	16.86	52	78.67	17.66
After session 4	45	78.31	22.23	38	81.55	21.81	41	83.93	20.41	42	75.76	22.91
After session 6	39	63.15	25.62	36	73.53	23.77	38	72.13	25.45	37	64.03	24.46
Posttreatment	35	53.00	29.02	34	61.76	24.00	38	62.74	27.34	31	50.68	25.06
3-month Follow-up	30	53.10	29.45	27	61.67	29.84	31	64.00	28.49	26	49.00	29.54
No MDD
Baseline	43	66.47	20.31	45	62.98	17.10	43	63.60	17.58	45	65.71	19.87
After session 4	37	74.14	17.26	30	59.10	22.06	32	68.22	19.55	35	66.66	22.15
After session 6	34	62.76	21.74	28	53.57	26.61	32	57.66	23.14	30	59.63	25.83
Posttreatment	34	51.82	24.17	27	36.56	19.20	31	43.74	22.16	30	46.43	24.59
3-month Follow-up	32	46.22	23.08	22	39.86	23.55	29	43.17	22.19	25	44.16	24.91
CAPS-IV, past week	Model-estimated statistics^a at posttreatment						Model-estimated statistics^a at posttreatment
	Mean difference (VRE vs. PE)		95%CI		p value	ES	Mean difference (DCS vs. placebo)		95%CI		p value	ES
MDD
Intent-to-treat analysis	3.51		(1.17, 5.86)		0.004	0.14	−8.43		(−10.98, −5.88)		<0.001	−0.42
No MDD
Intent-to-treat analysis	−8.87		(−11.33, −6.40)		<.001	−0.44	0.75		(−1.81, 3.30)		0.559	0.03

^aModel-estimated statistics are based on mixed-effects linear regression models examining change in CAPS-IV scores (past week) over time (baseline, after sessions 4 and 6, and posttreatment) with random intercepts and unstructured covariance structure. Intent to treat analysis: Exposure therapy (VRE vs. PE) by MDD interaction p value = 0.045; augmentation (DCS vs. placebo) by MDD interaction p value = 0.073. ES- standardized effect size (model-estimated between-group differences divided by the common standard deviation of the CAPS-IV changes scores baseline-posttreatment).

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Table 2 Descriptive and Model-estimated Statistics for Primary Outcome (CAPS-IV, past week): Exposure Therapy and Augmentation Over Time by Baseline MDD.

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