Fig. 2: Violin plot of BD-PRS by clinical group in European-ancestry individuals. | Translational Psychiatry

Fig. 2: Violin plot of BD-PRS by clinical group in European-ancestry individuals.

From: Epigenetic signatures relating to disease-associated genotypic burden in familial risk of bipolar disorder

Fig. 2

BD-PRS was standardised using the mean and standard deviation of all participants with genotype data (including an independent sample of BD cases and controls) regardless of availability of methylation data (n = 1699 controls, 354 HR, 355 BD; M = 0.0077695, SD = 7.543 × 10−5). The boxes and whiskers inside the violins indicate the 25–75th percentiles, and 1.5 times the interquartile range, respectively. The dashed rectangles indicate the stratification of HR participants into High-BD-PRS vs. Low-BD-PRS strata, as defined by the top and bottom two quintiles (i.e. 40% of the HR distribution), for the epigenome-wide association study. HR high risk, BD bipolar disorder, CON control, PRS polygenic risk score.

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