Table 1 Characteristics of patients with and without antidepressant exposure.

Variable	Number with missing data	Overall (N = 25,034)		With antidepressant exposure (N = 4577)		Without antidepressant exposure (N = 20,457)		P^a
Variable	Number with missing data	N or Median	% or IQR	N or Median	% or IQR	N or Median	% or IQR	P^a
Age (median, IQR)	0	47	32–61	53	39–65	46	31–60	<0.001
Sex	18							<0.001
Female		15,030	60.1	3383	73.9	11,647	57
Male		9986	39.9	1194	26.1	8792	43
Race	1250							<0.001
American Indian/Alaska Native		51	0.2	10	0.2	41	0.2
Asian		275	1.2	27	0.6	248	1.3
Black or African American		6389	26.9	716	15.8	5673	29.5
Other		7	<0.1	0	0	7	0
Other Pacific Islander		54	0.2	9	0.2	45	0.2
White		17,008	71.5	3782	83.2	13,226	68.7
Ethnicity	2909							<0.001
Hispanic		440	2.0	55	1.2	385	2.2
Non-hispanic		21,685	98.0	4376	98.8	17,309	97.8
Obese	3234	11,197	51.4	2619	57.5	8578	49.7	<0.001
Elixhauser Index (median, IQR)	1854	0	0–0	0	−4 to 3	0	0–0	<0.001
Mood or anxiety disorder	1854	5884	25.4	3283	71.7	2601	14	<0.001
Other psychiatric disorder	1854	2417	10.4	1057	23.1	1360	7.3	<0.001
Number of home medications	0							<0.001
0		11,149	44.5	0	0	11,149	54.5
01–05		4736	18.9	788	17.2	3948	19.3
06–10		3435	13.7	1036	22.6	2399	11.7
11–15		2382	9.5	928	20.3	1454	7.1
16+		3332	13.3	1825	39.9	1507	7.4
Benzodiazepine or Z drug	0	1997	8	1181	25.8	816	4	<0.001
Antipsychotic drug	0	582	2.3	452	9.9	130	0.6	<0.001
Non-antidepressant drug with FIASMA activity	0	4982	19.9	1949	42.6	3033	14.8	<0.001
Non-antidepressant drug with S1R activity	0	153	0.6	101	2.2	52	0.3	<0.001

FIASMA functional inhibition of acid sphingomyelinase, IQR interquartile range, S1R sigma-1 receptor.
^aP values calculated using Wilcoxon rank-sum test for age and Elixhauser Index. P values calculated using chi square test for all other variables.

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