Fig. 1: A proposed “interaction triangle” model between the circadian clock, mTOR signaling, and psychiatric diseases. | Translational Psychiatry

Fig. 1: A proposed “interaction triangle” model between the circadian clock, mTOR signaling, and psychiatric diseases.

From: The trilateral interactions between mammalian target of rapamycin (mTOR) signaling, the circadian clock, and psychiatric disorders: an emerging model

Fig. 1

1. The circadian clock temporally regulates mTOR activities in different tissues. 2. mTOR signaling regulates the central and peripheral circadian clock functions. 3. Psychiatric disorders can cause disruption of circadian rhythms. 4. Circadian dysfunction can contribute to the pathogenesis of psychiatric disorders. 5. Aberrant brain mTOR activities lead to psychiatric diseases. 6. Psychiatric disorders can lead to dysregulation of mTOR activities in the brain.

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