Fig. 6: Summary of neuroimaging, clinical, and transcriptomics analyses.
From: Microstructural imaging and transcriptomics of the basal forebrain in first-episode psychosis
(1) Clinical sample neuroimaging results examining case-control differences in microstructure, structure-MRS relationships, and clinical correlates of microstructure. We found increased qT1 and AxD in FEP compared to healthy controls (HC). In HC, there was a significant correlation between qT1 (left NBM) and MRS choline, while left NBM was related to negative (AxD) and manic symptom (qT1) burden. (2) Validation of basal forebrain microstructure measures using qT1 covariance between cortical and subcortical regions, and further external validation of cortical covariance by correlating with gene expression using the Allen Human Brain Atlas. Genes outlined are cholinergic receptor genes most positively associated with BF covariance for Ch1-3 and NBM, surviving FDR correction.
