Table 1 Summary of the GWASs used in two-sample Mendelian randomization analyses and multivariable Mendelian randomization.
From: Exploring the causal effects of genetic liability to ADHD and Autism on Alzheimer’s disease
Phenotype | PMID | Cohorts and samples | N |
|---|---|---|---|
ADHD | Demontis et al. [14] PMID: 30478444 | iPSYCH & PGC consortium | 20,183 cases 35,191 controls |
ASD | Grove et al. [19] PMID: 30804558 | iPSYCH & PGC consortium | 18,381 cases 27,969 controls |
Alzheimer’s | Jansen et al. [20] PMID: 30617256 | Phase 1: PGC-ALZ (DemGene, TwinGene, STSA), IGAP, ADSP Phase 2: Proxy-cases of Alzheimer’s disease in UKB Phase 3: Meta-analysis of Phase 1&2 | Phase1: 24,087 cases 55,058 controls Phase 3: 71,880 cases 383,378 controls |
Educational Attainment (Years of Schooling) | Lee et al. [24] PMID: 30038396 | Add Health, EGCUT, ELSA, FENLAND, Geisinger, GSII, NORFOLK, UKB, UKHLS, VIKING, WLS,ACPRC, AGE, ALSPAC, ASPS, BASE-II,CoLaus,COPSAC2000, CROATIA-Korčula, deCODE, DHS, DIL, ERF, FamHS, FINRISK, FTC, GOYA, GRAPHIC, GS, H2000 Cases, H2000 Controls, HBCS, HCS, HNRS (CorexB), HNRS (Oexpr), HNRS (Omni1), HRS, Hypergenes, INGI-CARL, INGI-FVG, KORA S3, KORA S4, LBC1921, LBC1936, LifeLines, MCTFR, MGS, MoBa, NBS, NESDA, NFBC66, NTR, OGP, OGP-Talana, ORCADES, PREVEND, QIMR, RS-I, RS-II, RS-III, Rush-MAP, Rush-ROS, SardiNIA, SHIP, SHIP-TREND, STR – Salty, STR – Twingene, THISEAS, TwinsUK, WTCCC58C, YFS | 766,345 participants |
Intelligence (IQ) | Savage et al. [25] PMID: 29942086 | UKB, COGENT, RS, GENR, STR, S4S, HiQ/HRS, TEDS, DTR-MADT, DTR-LSADT, IMAGEN, BLTS-Children, BLTS-Adolescence, NESCOG, GfG, STSA-SATSA + GENDER, STSA-HAMRONY | 269,867 participants |
