Table 5 Direct causal effects of genetic liability to ASD on Alzheimer’s disease, independent of (A) Educational Attainment (EA) (B) Intelligence (IQ).
From: Exploring the causal effects of genetic liability to ADHD and Autism on Alzheimer’s disease
Causal effect estimates | ||||
|---|---|---|---|---|
No. SNPs | OR | 95% CI | P-value | |
(A) Direct causal effect of ASD on AD, independent of EA | 7 | |||
Inverse-variance weighted | 0.99 | 0.98, 1.00 | 0.28 | |
MR-Egger | ||||
Intercept | 0.99 | 0.99, 1.00 | 0.60 | |
Estimate | 0.99 | 0.98, 1.01 | 0.72 | |
(B) Direct causal effect of ASD on AD, independent of IQ | 7 | |||
Inverse-variance weighted | 0.99 | 0.98, 1.01 | 0.99 | |
MR-Egger | ||||
Intercept | 1.00 | 0.99, 1.00 | 0.13 | |
Estimate | 0.98 | 0.96, 1.00 | 0.26 | |
