Fig. 6: Schematic diagram for PC overactivation mediates CSDS-induced learning and memory behaviors but not mood-related behavior. | Translational Psychiatry

Fig. 6: Schematic diagram for PC overactivation mediates CSDS-induced learning and memory behaviors but not mood-related behavior.

From: Social defeat drives hyperexcitation of the piriform cortex to induce learning and memory impairment but not mood-related disorders in mice

Fig. 6

After mice experienced chronic social defeat stress, the activity of PC-calcium signaling was increased, resulting in learning and memory impairment and mood-related disorders. Then, activation of PC CaMKIIα expressing neurons results in learning and memory dysfunction in mice, but not mood-related disorders. Inhibition of PC CaMKIIα expressing neurons in susceptible mice alleviated learning and memory impairment but had no significant effect on mood-related behavior.

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